What significance did the murder (Gen 4:8) hold for Jesus himself, as reported by Matthew and Luke?

Similar remarks from Jesus occur in both. On Matthew’s formulation, he warns his disciples that, as “prophets, and wise men, and scribes,” some of them should be killed and crucified, but that would be more of “the righteous blood shed upon the earth, from the blood of righteous Abel unto the blood of Zacharias son of Barachias” (Matt. 23:34-35). The suggestion in both places is that a tradition of martyrdom for righteousness began with Abel. So in Abel, Jesus finds the first martyr—a personal sacrifice both bloody and painful, but also honorable and necessary.